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Thavanesan, Navamayooran; Farahi, Arya; Parfitt, Charlotte; Belkhatir, Zehor; Azim, Tayyaba; Vallejos, Elvira Perez; Walters, Zoë; Ramchurn, Sarvapali; Underwood, Timothy J.; Vigneswaran, Ganesh
Insights from explainable AI in oesophageal cancer team decisions Journal Article
In: Computers in Biology and Medicine, vol. 180, 2024, (For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.).
Abstract | Links | BibTeX | Tags: Decision-making, machine learning, Multidisciplinary teams, Oesophageal cancer
@article{soton493238,
title = {Insights from explainable AI in oesophageal cancer team decisions},
author = {Navamayooran Thavanesan and Arya Farahi and Charlotte Parfitt and Zehor Belkhatir and Tayyaba Azim and Elvira Perez Vallejos and Zoë Walters and Sarvapali Ramchurn and Timothy J. Underwood and Ganesh Vigneswaran},
url = {https://eprints.soton.ac.uk/493238/},
year = {2024},
date = {2024-08-01},
journal = {Computers in Biology and Medicine},
volume = {180},
abstract = {ensuremath<pensuremath>Background: clinician-led quality control into oncological decision-making is crucial for optimising patient care. Explainable artificial intelligence (XAI) techniques provide data-driven approaches to unravel how clinical variables influence this decision-making. We applied global XAI techniques to examine the impact of key clinical decision-drivers when mapped by a machine learning (ML) model, on the likelihood of receiving different oesophageal cancer (OC) treatment modalities by the multidisciplinary team (MDT).ensuremath</pensuremath>ensuremath<pensuremath>Methods: retrospective analysis of 893 OC patients managed between 2010 and 2022 at our tertiary unit, used a random forests (RF) classifier to predict four possible treatment pathways as determined by the MDT: neoadjuvant chemotherapy followed by surgery (NACT + S), neoadjuvant chemoradiotherapy followed by surgery (NACRT + S), surgery-alone, and palliative management. Variable importance and partial dependence (PD) analyses then examined the influence of targeted high-ranking clinical variables within the ML model on treatment decisions as a surrogate model of the MDT decision-making dynamic.�ensuremath</pensuremath>ensuremath<pensuremath>Results: amongst guideline-variables known to determine treatments, such as Tumour-Node-Metastasis (TNM) staging, age also proved highly important to the RF model (16.1 % of total importance) on variable importance analysis. PD subsequently revealed that predicted probabilities for all treatment modalities change significantly after 75 years (p < 0.001). Likelihood of surgery-alone and palliative therapies increased for patients aged 75?85yrs but lowered for NACT/NACRT. Performance status divided patients into two clusters which influenced all predicted outcomes in conjunction with age.�ensuremath</pensuremath>ensuremath<pensuremath>Conclusion: XAI techniques delineate the relationship between clinical factors and OC treatment decisions. These techniques identify advanced age as heavily influencing decisions based on our model with a greater role in patients with specific tumour characteristics. This study methodology provides the means for exploring conscious/subconscious bias and interrogating inconsistencies in team-based decision-making within the era of AI-driven decision support.ensuremath</pensuremath>},
note = {For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.},
keywords = {Decision-making, machine learning, Multidisciplinary teams, Oesophageal cancer},
pubstate = {published},
tppubtype = {article}
}
Thavanesan, Navamayooran; Farahi, Arya; Parfitt, Charlotte; Belkhatir, Zehor; Azim, Tayyaba; Vallejos, Elvira Perez; Walters, Zoë; Ramchurn, Sarvapali; Underwood, Timothy J.; Vigneswaran, Ganesh
Insights from explainable AI in oesophageal cancer team decisions Journal Article
In: Computers in Biology and Medicine, vol. 180, 2024, (For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.).
@article{soton493238,
title = {Insights from explainable AI in oesophageal cancer team decisions},
author = {Navamayooran Thavanesan and Arya Farahi and Charlotte Parfitt and Zehor Belkhatir and Tayyaba Azim and Elvira Perez Vallejos and Zoë Walters and Sarvapali Ramchurn and Timothy J. Underwood and Ganesh Vigneswaran},
url = {https://eprints.soton.ac.uk/493238/},
year = {2024},
date = {2024-08-01},
journal = {Computers in Biology and Medicine},
volume = {180},
abstract = {ensuremath<pensuremath>Background: clinician-led quality control into oncological decision-making is crucial for optimising patient care. Explainable artificial intelligence (XAI) techniques provide data-driven approaches to unravel how clinical variables influence this decision-making. We applied global XAI techniques to examine the impact of key clinical decision-drivers when mapped by a machine learning (ML) model, on the likelihood of receiving different oesophageal cancer (OC) treatment modalities by the multidisciplinary team (MDT).ensuremath</pensuremath>ensuremath<pensuremath>Methods: retrospective analysis of 893 OC patients managed between 2010 and 2022 at our tertiary unit, used a random forests (RF) classifier to predict four possible treatment pathways as determined by the MDT: neoadjuvant chemotherapy followed by surgery (NACT + S), neoadjuvant chemoradiotherapy followed by surgery (NACRT + S), surgery-alone, and palliative management. Variable importance and partial dependence (PD) analyses then examined the influence of targeted high-ranking clinical variables within the ML model on treatment decisions as a surrogate model of the MDT decision-making dynamic.�ensuremath</pensuremath>ensuremath<pensuremath>Results: amongst guideline-variables known to determine treatments, such as Tumour-Node-Metastasis (TNM) staging, age also proved highly important to the RF model (16.1 % of total importance) on variable importance analysis. PD subsequently revealed that predicted probabilities for all treatment modalities change significantly after 75 years (p < 0.001). Likelihood of surgery-alone and palliative therapies increased for patients aged 75?85yrs but lowered for NACT/NACRT. Performance status divided patients into two clusters which influenced all predicted outcomes in conjunction with age.�ensuremath</pensuremath>ensuremath<pensuremath>Conclusion: XAI techniques delineate the relationship between clinical factors and OC treatment decisions. These techniques identify advanced age as heavily influencing decisions based on our model with a greater role in patients with specific tumour characteristics. This study methodology provides the means for exploring conscious/subconscious bias and interrogating inconsistencies in team-based decision-making within the era of AI-driven decision support.ensuremath</pensuremath>},
note = {For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Thavanesan, Navamayooran; Farahi, Arya; Parfitt, Charlotte; Belkhatir, Zehor; Azim, Tayyaba; Vallejos, Elvira Perez; Walters, Zoë; Ramchurn, Sarvapali; Underwood, Timothy J.; Vigneswaran, Ganesh
Insights from explainable AI in oesophageal cancer team decisions Journal Article
In: Computers in Biology and Medicine, vol. 180, 2024, (For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.).
Abstract | Links | BibTeX | Tags: Decision-making, machine learning, Multidisciplinary teams, Oesophageal cancer
@article{soton493238,
title = {Insights from explainable AI in oesophageal cancer team decisions},
author = {Navamayooran Thavanesan and Arya Farahi and Charlotte Parfitt and Zehor Belkhatir and Tayyaba Azim and Elvira Perez Vallejos and Zoë Walters and Sarvapali Ramchurn and Timothy J. Underwood and Ganesh Vigneswaran},
url = {https://eprints.soton.ac.uk/493238/},
year = {2024},
date = {2024-08-01},
journal = {Computers in Biology and Medicine},
volume = {180},
abstract = {ensuremath<pensuremath>Background: clinician-led quality control into oncological decision-making is crucial for optimising patient care. Explainable artificial intelligence (XAI) techniques provide data-driven approaches to unravel how clinical variables influence this decision-making. We applied global XAI techniques to examine the impact of key clinical decision-drivers when mapped by a machine learning (ML) model, on the likelihood of receiving different oesophageal cancer (OC) treatment modalities by the multidisciplinary team (MDT).ensuremath</pensuremath>ensuremath<pensuremath>Methods: retrospective analysis of 893 OC patients managed between 2010 and 2022 at our tertiary unit, used a random forests (RF) classifier to predict four possible treatment pathways as determined by the MDT: neoadjuvant chemotherapy followed by surgery (NACT + S), neoadjuvant chemoradiotherapy followed by surgery (NACRT + S), surgery-alone, and palliative management. Variable importance and partial dependence (PD) analyses then examined the influence of targeted high-ranking clinical variables within the ML model on treatment decisions as a surrogate model of the MDT decision-making dynamic.�ensuremath</pensuremath>ensuremath<pensuremath>Results: amongst guideline-variables known to determine treatments, such as Tumour-Node-Metastasis (TNM) staging, age also proved highly important to the RF model (16.1 % of total importance) on variable importance analysis. PD subsequently revealed that predicted probabilities for all treatment modalities change significantly after 75 years (p < 0.001). Likelihood of surgery-alone and palliative therapies increased for patients aged 75?85yrs but lowered for NACT/NACRT. Performance status divided patients into two clusters which influenced all predicted outcomes in conjunction with age.�ensuremath</pensuremath>ensuremath<pensuremath>Conclusion: XAI techniques delineate the relationship between clinical factors and OC treatment decisions. These techniques identify advanced age as heavily influencing decisions based on our model with a greater role in patients with specific tumour characteristics. This study methodology provides the means for exploring conscious/subconscious bias and interrogating inconsistencies in team-based decision-making within the era of AI-driven decision support.ensuremath</pensuremath>},
note = {For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.},
keywords = {Decision-making, machine learning, Multidisciplinary teams, Oesophageal cancer},
pubstate = {published},
tppubtype = {article}
}
Thavanesan, Navamayooran; Farahi, Arya; Parfitt, Charlotte; Belkhatir, Zehor; Azim, Tayyaba; Vallejos, Elvira Perez; Walters, Zoë; Ramchurn, Sarvapali; Underwood, Timothy J.; Vigneswaran, Ganesh
Insights from explainable AI in oesophageal cancer team decisions Journal Article
In: Computers in Biology and Medicine, vol. 180, 2024, (For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.).
@article{soton493238,
title = {Insights from explainable AI in oesophageal cancer team decisions},
author = {Navamayooran Thavanesan and Arya Farahi and Charlotte Parfitt and Zehor Belkhatir and Tayyaba Azim and Elvira Perez Vallejos and Zoë Walters and Sarvapali Ramchurn and Timothy J. Underwood and Ganesh Vigneswaran},
url = {https://eprints.soton.ac.uk/493238/},
year = {2024},
date = {2024-08-01},
journal = {Computers in Biology and Medicine},
volume = {180},
abstract = {ensuremath<pensuremath>Background: clinician-led quality control into oncological decision-making is crucial for optimising patient care. Explainable artificial intelligence (XAI) techniques provide data-driven approaches to unravel how clinical variables influence this decision-making. We applied global XAI techniques to examine the impact of key clinical decision-drivers when mapped by a machine learning (ML) model, on the likelihood of receiving different oesophageal cancer (OC) treatment modalities by the multidisciplinary team (MDT).ensuremath</pensuremath>ensuremath<pensuremath>Methods: retrospective analysis of 893 OC patients managed between 2010 and 2022 at our tertiary unit, used a random forests (RF) classifier to predict four possible treatment pathways as determined by the MDT: neoadjuvant chemotherapy followed by surgery (NACT + S), neoadjuvant chemoradiotherapy followed by surgery (NACRT + S), surgery-alone, and palliative management. Variable importance and partial dependence (PD) analyses then examined the influence of targeted high-ranking clinical variables within the ML model on treatment decisions as a surrogate model of the MDT decision-making dynamic.�ensuremath</pensuremath>ensuremath<pensuremath>Results: amongst guideline-variables known to determine treatments, such as Tumour-Node-Metastasis (TNM) staging, age also proved highly important to the RF model (16.1 % of total importance) on variable importance analysis. PD subsequently revealed that predicted probabilities for all treatment modalities change significantly after 75 years (p < 0.001). Likelihood of surgery-alone and palliative therapies increased for patients aged 75?85yrs but lowered for NACT/NACRT. Performance status divided patients into two clusters which influenced all predicted outcomes in conjunction with age.�ensuremath</pensuremath>ensuremath<pensuremath>Conclusion: XAI techniques delineate the relationship between clinical factors and OC treatment decisions. These techniques identify advanced age as heavily influencing decisions based on our model with a greater role in patients with specific tumour characteristics. This study methodology provides the means for exploring conscious/subconscious bias and interrogating inconsistencies in team-based decision-making within the era of AI-driven decision support.ensuremath</pensuremath>},
note = {For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Multi-agent signal-less intersection management with dynamic platoon formation
AI Foundation Models: initial review, CMA Consultation, TAS Hub Response
The effect of data visualisation quality and task density on human-swarm interaction
Demonstrating performance benefits of human-swarm teaming
Thavanesan, Navamayooran; Farahi, Arya; Parfitt, Charlotte; Belkhatir, Zehor; Azim, Tayyaba; Vallejos, Elvira Perez; Walters, Zoë; Ramchurn, Sarvapali; Underwood, Timothy J.; Vigneswaran, Ganesh
Insights from explainable AI in oesophageal cancer team decisions Journal Article
In: Computers in Biology and Medicine, vol. 180, 2024, (For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.).
@article{soton493238,
title = {Insights from explainable AI in oesophageal cancer team decisions},
author = {Navamayooran Thavanesan and Arya Farahi and Charlotte Parfitt and Zehor Belkhatir and Tayyaba Azim and Elvira Perez Vallejos and Zoë Walters and Sarvapali Ramchurn and Timothy J. Underwood and Ganesh Vigneswaran},
url = {https://eprints.soton.ac.uk/493238/},
year = {2024},
date = {2024-08-01},
journal = {Computers in Biology and Medicine},
volume = {180},
abstract = {ensuremath<pensuremath>Background: clinician-led quality control into oncological decision-making is crucial for optimising patient care. Explainable artificial intelligence (XAI) techniques provide data-driven approaches to unravel how clinical variables influence this decision-making. We applied global XAI techniques to examine the impact of key clinical decision-drivers when mapped by a machine learning (ML) model, on the likelihood of receiving different oesophageal cancer (OC) treatment modalities by the multidisciplinary team (MDT).ensuremath</pensuremath>ensuremath<pensuremath>Methods: retrospective analysis of 893 OC patients managed between 2010 and 2022 at our tertiary unit, used a random forests (RF) classifier to predict four possible treatment pathways as determined by the MDT: neoadjuvant chemotherapy followed by surgery (NACT + S), neoadjuvant chemoradiotherapy followed by surgery (NACRT + S), surgery-alone, and palliative management. Variable importance and partial dependence (PD) analyses then examined the influence of targeted high-ranking clinical variables within the ML model on treatment decisions as a surrogate model of the MDT decision-making dynamic.�ensuremath</pensuremath>ensuremath<pensuremath>Results: amongst guideline-variables known to determine treatments, such as Tumour-Node-Metastasis (TNM) staging, age also proved highly important to the RF model (16.1 % of total importance) on variable importance analysis. PD subsequently revealed that predicted probabilities for all treatment modalities change significantly after 75 years (p < 0.001). Likelihood of surgery-alone and palliative therapies increased for patients aged 75?85yrs but lowered for NACT/NACRT. Performance status divided patients into two clusters which influenced all predicted outcomes in conjunction with age.�ensuremath</pensuremath>ensuremath<pensuremath>Conclusion: XAI techniques delineate the relationship between clinical factors and OC treatment decisions. These techniques identify advanced age as heavily influencing decisions based on our model with a greater role in patients with specific tumour characteristics. This study methodology provides the means for exploring conscious/subconscious bias and interrogating inconsistencies in team-based decision-making within the era of AI-driven decision support.ensuremath</pensuremath>},
note = {For the purpose of open access, the authors have applied a Creative Commons attribution license (CC-BY) to any Author Accepted Manuscript version arising from this submission.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}